mrspoonsi (2955715) writes A project aiming to revolutionise medicine by unlocking the secrets of DNA is under way in centres across England. Prime Minister David Cameron has said it "will see the UK lead the world in genetic research within years". The first genetic codes of people with cancer or rare diseases, out of a target of 100,000, have been sequenced. Experts believe it will lead to targeted therapies and could make chemotherapy "a thing of the past". Just one human genome contains more than three billion base pairs — the building blocks of DNA. Prof Jeremy Farrar, director of the Wellcome Trust, said: "I can see a future where genetics is going to come into every bit of medicine from cardiology to oncology to infectious diseases." "Twenty years from now there's going to be a plethora of those, we will have a series of mutations which academics and industry will have developed therapies for, which will be targeted at you and specific for that cancer." He said chemotherapy, which attacks all dividing cells in the body, would be replaced with such therapies. "We will look back in 20 years' time and think of blockbuster chemotherapy [as] a thing of the past and we'll think 'Gosh, what an era that was'." David Cameron has announced a series of investments across government, industry and charities totalling £300m ($500m).
acidradio (659704) writes American air charter specialist Phoenix Air has been contracted by the U.S. Army to haul an American physician afflicted with Ebola from Liberia to the Emory University Hospital in Atlanta. This will be the first 'purposeful' transport of an Ebola victim to the U.S. The patient will be flown in a special Gulfstream III (formerly owned by the Danish Air Force) outfitted for very specialized medical transports such as this. I dunno. I know there are brilliant doctors and scientists in Atlanta who handle highly-communicable diseases, but is this such a brilliant idea? theodp (442580) writes with related news In response to the Ebola outbreak, the Centers for Disease Control and Prevention (CDC) has issued Interim Guidance about Ebola Virus Infection for Airline Flight Crews, Cleaning Personnel, and Cargo Personnel. "Ebola virus is transmitted by close contact with a person who has symptoms of Ebola," the CDC explains. "Close contact is defined as having cared for or lived with a person with Ebola or having a high likelihood of direct contact with blood or body fluids of an Ebola patient. Examples of close contact include kissing or embracing, sharing eating or drinking utensils, close conversation (3 feet), physical examination, and any other direct physical contact between people. Close contact does not include walking by a person or briefly sitting across a room from a person."
Jason Koebler (3528235) writes To help people overcome drug addiction, researchers at the University of Houston's Graduate School of Social Work are building hyper-realistic virtual worlds to recreate situations that trigger cravings for nicotine, alcohol, weed, and now, hard drugs like heroin. Traditional relapse therapy usually involves roleplaying: Therapists often pretend to be a friend or some other familiar person and offer the patient their drug of choice in order to teach them avoidance strategies. By strapping patients into a virtual reality headset and running them through a familiar scenario where they commonly use the drug, like a party, the treatment can be much more realistic and effective, researchers say (video).
gallifreyan99 writes: Every drug you take will have been tested on people before it—but that testing process is meant to be tightly controlled, for the safety of everyone involved. Two investigations document the questionable methods used in many studies, and the lack of oversight the FDA seems to have over the process. First, drugs are increasingly being tested on homeless, destitute and mentally ill people. Second, it turns out many human trials are being run by doctors who have had their licenses revoked for drug addiction, malpractice and worse.
An anonymous reader writes UK researchers say they've devised a simple blood test that can be used to diagnose whether people have cancer or not. The Lymphocyte Genome Sensitivity (LGS) test looks at white blood cells and measures the damage caused to their DNA when subjected to different intensities of ultraviolet light (UVA), which is known to damage DNA. The results of the empirical study show a distinction between the damage to the white blood cells from patients with cancer, with pre-cancerous conditions and from healthy patients. "Whilst the numbers of people we tested are, in epidemiological terms, quite small (208), in molecular epidemiological terms, the results are powerful," said the team's lead researcher. "We've identified significant differences between the healthy volunteers, suspected cancer patients and confirmed cancer patients of mixed ages at a statistically significant level .... This means that the possibility of these results happening by chance is 1 in 1000." The research is published online in the FASEB Journal, the U.S. Journal of the Federation of American Societies for Experimental Biology.
sciencehabit (1205606) writes "Pregnant women who smoke don't just harm the health of their baby—they may actually impair their child's DNA, according to new research. A genetic analysis shows that the children of mothers who smoke harbor far more chemical modifications of their genome — known as epigenetic changes — than kids of non-smoking mothers. Many of these are on genes tied to addiction and fetal development. The finding may explain why the children of smokers continue to suffer health complications later in life.
A newly discovered virus has been found by a San Diego State University team to live inside more than half of all human gut cells sampled. Exploring genetic material found in intestinal samples, the international team uncovered the CrAssphage virus. They say the virus could influence the behaviour of some of the most common bacteria in our gut. Researchers say the virus has the genetic fingerprint of a bacteriophage - a type of virus known to infect bacteria. Phages may work to control the behaviour of bacteria they infect - some make it easier for bacteria to inhabit in their environments while others allow bacteria to become more potent. [Study lead Dr. Robert] Edwards said: "In some way phages are like wolves in the wild, surrounded by hares and deer. "They are critical components of our gut ecosystems, helping control the growth of bacterial populations and allowing a diversity of species." According to the team, CrAssphage infects one of the most common types of bacteria in our guts. National Geographic gives some idea why a virus so common in our gut should have evaded discovery for so long, but at least CrAssphage finally has a Wikipedia page of its own.
hweimer (709734) writes "German long jumper Markus Rehm has written sports history yesterday, becoming the first disabled athlete to win a national able-bodied championship. His jump to 8.24 meters put him on the 9th place of the current season rankings and make him egligible to compete in the upcoming European championships, further sparking the debate whether his prosthetic leg provides him with an unfair advantage."
jigmypig (3675225) writes "Two patients in South Africa that have had their lives and more specifically their jaws severely affected by cancer, have just received 3D printed jaw implants. The jaws were 3D printed using a laser sintering process that melts powdered titanium, one layer at a time. The process saves a ton of money, and unlike traditional manufacturing of titanium jaws, it doesn't waste any materials. Traditional manufacturing wastes up to 80% of the titanium block used in the process, whereas with 3D printing there is little to no waste at all. This new process also allows for a fully customizable solution. The models are drawn up in CAD software, and then printed out to precisely fit the patient."
rtoz writes: Google's moonshot research division, "Google X," has started "Baseline Study," a project designed to collect anonymous genetic and molecular information from 175 people (and later thousands more) to create a complete picture of what a healthy human being should be. The blueprint will help researchers detect health problems such as heart disease and cancer far earlier, focusing medicine on prevention rather than treatment. According to Google, the information from Baseline will be anonymous, and its use will be limited to medical and health purposes. Data won't be shared with insurance companies.
First time accepted submitter Leslie Oliver Karpas writes As millions of Americans with Obstructive Sleep Apnea struggle to get a good night's sleep, one company has harnessed 3D technology to revolutionize CPAP therapy. As 3ders.org reported today, "Metamason is working on custom CPAP masks for sleep apnea patients via 3D scanning, smart geometry, and 3D printing." "We're at the crossroads of 3D technology and personalized medicine," says Metamason's founder and CEO. "There are many medical products that would be infinitely more comfortable and effective with a customized fit. CPAP therapy is the perfect example—it's a very effective treatment with a 50% quit rate, because mass-produced masks are uncomfortable and don't fit properly." CPAP is a respiratory device worn during sleep to treat OSA, which affects 1 in 4 men and 1 in 9 women in the US alone. Metamason's "ScanFitPrint" process for creating their custom Respere masks translates a 3D scan of the patient's face into a 3D printed custom mask that is a perfect individual fit. To print the masks in soft, biocompatible silicone, Metamason invented a proprietary 3D printing process called Investment Molding, which creates wholly integrated products that were previously considered "unmoldable."
gunner_von_diamond (3461783) happened upon Ask Slashdot: Experiences with Laser Eye Surgery from ten years ago, and asks: I was just reading a story on /. from 10 years ago about Lasik Eye Surgery. Personally, I've had Lasik done and loved every single part of the surgery. I went from wearing contacts/glasses every day to having 20/15 vision! In the older post, everyone seemed to be cautious about it, waiting for technical advances before having the surgery. Today, the surgery is fairly inexpensive [even for a programmer :) ], takes about 10-15 minutes, and I recovered from the surgery that same day. So my question is: what is holding everyone else back from freeing themselves from contacts and glasses?
symbolset writes in with the latest about an ebola outbreak spreading across West Africa. The World Health Organization (WHO) continues to monitor the evolution of the Ebola virus disease (EVD) outbreak in Sierra Leone, Liberia, and Guinea. The current epidemic trend of EVD outbreak in Sierra Leone and Liberia remains serious, with 67 new cases and 19 deaths reported July 15-17, 2014. These include suspect, probable, and laboratory-confirmed cases. The EVD outbreak in Guinea continues to show a declining trend, with no new cases reported during this period. Critical analyses and review of the current outbreak response is being undertaken to inform the process of developing prioritized national operational plans. Effective implementation of the prioritized plans will be vital in reversing the current trend of EVD outbreak, especially in Liberia and Sierra Leone.
Lasrick writes: MIT's Jeanne Guillemin looks at the recent blunders with smallpox and H5N1 at the Centers for Disease Control and the National Institutes of Health to chronicle the fascinating history of smallpox eradication efforts and the attempts (thwarted by Western scientists) to destroy lab collections of the virus in order to make it truly extinct. "In 1986, with no new smallpox cases reported, the World Health Assembly, the decision-making body of the WHO, resolved to destroy the strain collections and make the virus extinct. But there was resistance to this; American scientists in particular wanted to continue their research." Within a few years, secret biological warfare programs were discovered in Moscow and in Iraq, and a new flurry of defensive research was funded. Nevertheless, Guillemin and others believe that changes in research methods, which no longer require the use of live viruses, mean that stocks of the live smallpox virus can and should finally be destroyed.
rtoz (2530056) writes A special class of tiny gold particles can easily slip through cell membranes, making them good candidates to deliver drugs directly to target cells. A new study from MIT materials scientists reveals that these nanoparticles enter cells by taking advantage of a route normally used in vesicle-vesicle fusion, a crucial process that allows signal transmission between neurons. MIT engineers created simulations of how a gold nanoparticle coated with special molecules can penetrate a membrane. Paper (abstract; full text paywalled).
New submitter structural_biologist writes: Genes normally have a 50-50 chance of being passed from parent to offspring, but scientists may have figured out a way to create genes that show up in offspring with a much higher frequency. "One type of gene drive influences inheritance by copying itself onto chromosomes that previously lacked it. When an organism inherits such a gene drive from only one parent, it makes a cut in the chromosome from the other parent, forcing the cell to copy the inheritance-biasing gene drive—and any adjacent genes—when it repairs the damage." When introduced into the wild, organisms containing gene drives would breed with the population, quickly spreading the modified genes throughout the ecosystem. While the technology could help prevent the spread of malaria and manage invasive species, many scientists worry about the wide-ranging effects of such a technology and are calling for its regulation.
Zothecula (1870348) writes Pacemakers serve an invaluable purpose, by electrically stimulating a recipient's heart in order to keep it beating at a steady rate. The implantation of a pacemaker is a major surgical procedure, however, plus its presence in the body can lead to complications such as infections. Now, for the first time, scientists have instead injected genes into the defective hearts of pigs, converting unspecialized heart cells into "biological pacemakers." Research Paper (abstract, full text paywalled).
multicsfan writes Researchers have found that an injection of protein FGF1 stops weight induced diabetes in mice, with no apparent side effects. However, the cure only lasts 2 days at a time. Future research and human trials are needed to better understand and create a working drug. From the story: "The team found that sustained treatment with the protein doesn't merely keep blood sugar under control, but also reverses insulin insensitivity, the underlying physiological cause of diabetes. Equally exciting, the newly developed treatment doesn't result in side effects common to most current diabetes treatments."
aarondubrow (1866212) writes The "valley of death" is well-known to entrepreneurs — the lull between government funding for research and industry support for prototypes and products. To confront this problem, in 2013 the National Science Foundation created a new program called InTrans to extend the life of the most high-impact NSF-funded research and help great ideas transition from lab to practice. Today, in partnership with Intel, NSF announced the first InTrans award of $3 million to a team of researchers who are designing customizable, domain-specific computing technologies for use in healthcare. The work could lead to less exposure to dangerous radiation during x-rays by speeding up the computing side of medicine. It also could result in patient-specific cancer treatments.
schwit1 (797399) writes FDA officials now admit that when they discovered six undocumented vials of smallpox in a facility in Maryland they also found 327 additional vials that contained dengue, influenza, and rickettsia. "FDA scientists said they have not yet confirmed whether the newly disclosed vials actually contained the pathogens listed on their labels. The agency is conducting a nationwide search of all cold storage units for any other missing samples. Investigators destroyed 32 vials containing tissue samples and a non-contagious virus related to smallpox. Several unlabeled vials were sent to the Centers for Disease Control and Prevention for testing and the remaining 279 samples were shipped to the Department of Homeland Security for safekeeping." The FDA's deputy director is quoted with what might be the understatement of the year. "The reasons why these samples went unnoticed for this long is something we're actively trying to understand."