Stop using bloated frameworks for webpages. If you want to make an application, WRITE A GODDAMNED APPLICATION!

And what language and platform should one do this? Windows? Seems pretty reasonable - after all, no one uses macOS or Linux, right? Or Android or iOS.

Or maybe we do Android, and ignore iOS and Windows and people who use desktops?

The reality is - the web browser has become the universal platform. With very little code, you can write an application in a web browser that runs on practically all platforms, even ones you think no one cares about (hello Windows Phone). It's the universal runtime, something you can consider that practically everyone who will use your application has access to.

Oh, and people are writing applications as applications. Thanks to stuff like NodeJS, what's happening is the "application" is really a web browser hard coded to a specific web site.